AustralieFrV1, Main, Exploration, bibRecord, 004523

REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH

Identifieur interne : 004523 ( Main/Exploration ); précédent : 004522; suivant : 004524

REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH

Auteurs : Vikas Gupta [Canada] ; Adriana K. Malone [États-Unis] ; Parameswaran N. Hari [États-Unis] ; Kwang Woo Ahn [États-Unis] ; Zhen-Huan Hu [États-Unis] ; Robert Peter Gale [Royaume-Uni] ; Karen K. Ballen [États-Unis] ; Mehdi Hamadani [États-Unis] ; Eduardo Olavarria [Espagne] ; Aaron T. Gerds [États-Unis] ; Edmund K. Waller [États-Unis] ; Luciano J. Costa [États-Unis] ; Joseph H. Antin [États-Unis] ; Rammurti T. Kamble [États-Unis] ; Koen M. Van Besien [États-Unis] ; Bipin N. Savani [États-Unis] ; Harry C. Schouten [Pays-Bas] ; Jeffrey Szer [Australie] ; Jean-Yves Cahn [France] ; Marcos J. De Lima [États-Unis] ; Baldeep Wirk [États-Unis] ; Mahmoud D. Aljurf [Arabie saoudite] ; Uday Popat [États-Unis] ; Nelli Bejanyan [États-Unis] ; Mark R. Litzow [États-Unis] ; Maxim Norkin [États-Unis] ; Ian D. Lewis [Australie] ; Gregory A. Hale [États-Unis] ; Ann E. Woolfrey [États-Unis] ; Alan M. Miller [États-Unis] ; Celalettin Ustun [États-Unis] ; Madan H. Jagasia [États-Unis] ; Michael Lill [États-Unis] ; Richard T. Maziarz [États-Unis] ; Jorge Cortes [États-Unis] ; Matt E. Kalaycio [États-Unis] ; Wael Saber [États-Unis]

Source :

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1083-8791 ] ; 2013.

RBID : PMC:3886623

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Agonistes myélo-ablatifs (usage thérapeutique), Analyse de survie, Analyse multivariée, Antigènes HLA (immunologie), Conditionnement pour greffe (), Donneurs non apparentés (), Femelle, Fratrie, Humains, Myélofibrose primitive (), Myélofibrose primitive (anatomopathologie), Myélofibrose primitive (immunologie), Myélofibrose primitive (mortalité), Mâle, Pronostic, Risque, Récidive, Sujet âgé, Test d'histocompatibilité, Transplantation de cellules souches hématopoïétiques, Transplantation homologue, Études de cohortes.
MESH :
- anatomopathologie : Myélofibrose primitive.
- immunologie : Antigènes HLA, Myélofibrose primitive.
- mortalité : Myélofibrose primitive.
- usage thérapeutique : Agonistes myélo-ablatifs.
- Adulte, Adulte d'âge moyen, Analyse de survie, Analyse multivariée, Conditionnement pour greffe, Donneurs non apparentés, Femelle, Fratrie, Humains, Myélofibrose primitive, Mâle, Pronostic, Risque, Récidive, Sujet âgé, Test d'histocompatibilité, Transplantation de cellules souches hématopoïétiques, Transplantation homologue, Études de cohortes.

English descriptors

KwdEn :
- Adult, Aged, Cohort Studies, Female, HLA Antigens (immunology), Hematopoietic Stem Cell Transplantation, Histocompatibility Testing, Humans, Male, Middle Aged, Multivariate Analysis, Myeloablative Agonists (therapeutic use), Primary Myelofibrosis (immunology), Primary Myelofibrosis (mortality), Primary Myelofibrosis (pathology), Primary Myelofibrosis (therapy), Prognosis, Recurrence, Risk, Siblings, Survival Analysis, Transplantation Conditioning (methods), Transplantation, Homologous, Unrelated Donors (classification).
MESH :
- chemical , immunology : HLA Antigens.
- chemical , therapeutic use : Myeloablative Agonists.
- classification : Unrelated Donors.
- immunology : Primary Myelofibrosis.
- methods : Transplantation Conditioning.
- mortality : Primary Myelofibrosis.
- pathology : Primary Myelofibrosis.
- therapy : Primary Myelofibrosis.
- Adult, Aged, Cohort Studies, Female, Hematopoietic Stem Cell Transplantation, Histocompatibility Testing, Humans, Male, Middle Aged, Multivariate Analysis, Prognosis, Recurrence, Risk, Siblings, Survival Analysis, Transplantation, Homologous.

Abstract

We evaluated the outcomes and associated prognostic factors in 233 patients undergoing allogeneic hematopoietic cell transplantation (HCT) for primary myelofibrosis (MF) using reduced intensity conditioning (RIC). Median age at HCT was 55 years. Donors were: matched sibling donor (MSD), 34%; HLA-well-matched unrelated donors (URD), 45%; and partially/mismatched URD, 21%. Risk stratification according to Dynamic International Prognostic Scoring System (DIPSS): low, 12%; intermediate-1, 49%; intermediate-2, 37%; and high, 1%. The probability of survival at 5-years was 47% (95% CI 40–53). In a multivariate analysis, donor type was the only independent factor associated with survival. Adjusted probabilities of survival at 5-years for MSD, well matched URD and partially matched/mismatched URD were 56% (95% CI 44–67), 48% (95% CI 37–58), and 34% (95% CI 21–47), respectively (p=0.002). Relative risks (RR) for NRM for well-matched URD and partially matched/mismatched URD were 3.92 (p=0.006) and 9.37 (p<0.0001), respectively. A trend towards increased NRM (RR 1.7, p=0.07) and inferior survival (RR 1.37, p=0.10) was observed in DIPSS-intermediate-2/high-risk patients compared to DIPSS-low/intermediate-1 risk patients.

RIC HCT is a potentially curative option for patients with MF, and donor type is the most important factor influencing survival in these patients.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886623

DOI: 10.1016/j.bbmt.2013.10.018
PubMed: 24161923
PubMed Central: 3886623

Affiliations:

Arabie saoudite, Australie, Canada, Espagne, France, Pays-Bas, Royaume-Uni, États-Unis
Angleterre, Auvergne-Rhône-Alpes, Californie, Caroline du Sud, Floride, Grand Londres, Géorgie (États-Unis), Massachusetts, Minnesota, Ohio, Ontario, Oregon, Rhône-Alpes, Tennessee, Texas, Virginie-Occidentale, Wisconsin, État de New York
Grenoble, Londres, Toronto
Université de Toronto

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH</title>
<author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Princess Margaret Cancer Center, University of Toronto, Toronto, CANADA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea>Princess Margaret Cancer Center, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malone, Adriana K" sort="Malone, Adriana K" uniqKey="Malone A" first="Adriana K." last="Malone">Adriana K. Malone</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Mount Sinai Medical Center, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Mount Sinai Medical Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hari, Parameswaran N" sort="Hari, Parameswaran N" uniqKey="Hari P" first="Parameswaran N." last="Hari">Parameswaran N. Hari</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name>
<affiliation wicri:level="3"><nlm:aff id="A4">Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, UNITED KINGDOM</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K." last="Ballen">Karen K. Ballen</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Massachusetts General Hospital, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name>
<affiliation wicri:level="2"><nlm:aff id="A6">West Virginia University Hospitals, Inc., Morgantown, WV</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie-Occidentale</region>
</placeName>
<wicri:cityArea>West Virginia University Hospitals, Inc., Morgantown</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Olavarria, Eduardo" sort="Olavarria, Eduardo" uniqKey="Olavarria E" first="Eduardo" last="Olavarria">Eduardo Olavarria</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Hematology Department and BMT Unit, Complejo Hospitalario de Navarra, Pamplona, SPAIN</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Espagne</country>
<wicri:regionArea>Hematology Department and BMT Unit, Complejo Hospitalario de Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gerds, Aaron T" sort="Gerds, Aaron T" uniqKey="Gerds A" first="Aaron T." last="Gerds">Aaron T. Gerds</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Blood and Marrow Transplant Program, Medical University of South Carolina, Charleston, SC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Sud</region>
</placeName>
<wicri:cityArea>Blood and Marrow Transplant Program, Medical University of South Carolina, Charleston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H." last="Antin">Joseph H. Antin</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Dana Farber Cancer Institute, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Cell and Gene Therapy, Baylor College of Medicine, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van Besien, Koen M" sort="Van Besien, Koen M" uniqKey="Van Besien K" first="Koen M." last="Van Besien">Koen M. Van Besien</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Stem Cell Transplant, Weill Cornell Medical College, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Stem Cell Transplant, Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Academische Ziekenhuis Maastricht, Maastricht, NETHERLANDS</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Academische Ziekenhuis Maastricht, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Clinical Haematology and BMT Service, Royal Melbourne Hospital, Victoria, AUSTRALIA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea>Clinical Haematology and BMT Service, Royal Melbourne Hospital, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
<affiliation wicri:level="3"><nlm:aff id="A17">Department of Hematology, University Hospital, Grenoble, FRANCE</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Lima, Marcos J" sort="De Lima, Marcos J" uniqKey="De Lima M" first="Marcos J." last="De Lima">Marcos J. De Lima</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name>
<affiliation wicri:level="2"><nlm:aff id="A19">Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name>
<affiliation wicri:level="1"><nlm:aff id="A20">King Faisal Specialist Hospital and Research Center, Riyadh, SAUDI ARABIA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Arabie saoudite</country>
<wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Popat, Uday" sort="Popat, Uday" uniqKey="Popat U" first="Uday" last="Popat">Uday Popat</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bejanyan, Nelli" sort="Bejanyan, Nelli" uniqKey="Bejanyan N" first="Nelli" last="Bejanyan">Nelli Bejanyan</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Mayo Clinic Rochester, Rochester, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Norkin, Maxim" sort="Norkin, Maxim" uniqKey="Norkin M" first="Maxim" last="Norkin">Maxim Norkin</name>
<affiliation wicri:level="2"><nlm:aff id="A19">Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide, AUSTRALIA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea>Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name>
<affiliation wicri:level="2"><nlm:aff id="A25">All Children's Hospital, St. Petersburg, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>All Children's Hospital, St. Petersburg</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Woolfrey, Ann E" sort="Woolfrey, Ann E" uniqKey="Woolfrey A" first="Ann E." last="Woolfrey">Ann E. Woolfrey</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Baylor University Medical Center, Dallas, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Baylor University Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jagasia, Madan H" sort="Jagasia, Madan H" uniqKey="Jagasia M" first="Madan H." last="Jagasia">Madan H. Jagasia</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lill, Michael" sort="Lill, Michael" uniqKey="Lill M" first="Michael" last="Lill">Michael Lill</name>
<affiliation wicri:level="2"><nlm:aff id="A27">Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name>
<affiliation wicri:level="2"><nlm:aff id="A28">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Oregon</region>
</placeName>
<wicri:cityArea>Center for Hematologic Malignancies, Oregon Health and Science University, Portland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24161923</idno>
<idno type="pmc">3886623</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886623</idno>
<idno type="RBID">PMC:3886623</idno>
<idno type="doi">10.1016/j.bbmt.2013.10.018</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">002187</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002187</idno>
<idno type="wicri:Area/Pmc/Curation">002038</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002038</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001925</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001925</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">003A52</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003A52</idno>
<idno type="wicri:Area/PubMed/Curation">003923</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003923</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003923</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003923</idno>
<idno type="wicri:Area/Ncbi/Merge">001538</idno>
<idno type="wicri:Area/Ncbi/Curation">001538</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001538</idno>
<idno type="wicri:doubleKey">1083-8791:2013:Gupta V:reduced:intensity:hematopoietic</idno>
<idno type="wicri:Area/Main/Merge">004614</idno>
<idno type="wicri:Area/Main/Curation">004523</idno>
<idno type="wicri:Area/Main/Exploration">004523</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH</title>
<author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Princess Margaret Cancer Center, University of Toronto, Toronto, CANADA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea>Princess Margaret Cancer Center, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malone, Adriana K" sort="Malone, Adriana K" uniqKey="Malone A" first="Adriana K." last="Malone">Adriana K. Malone</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Mount Sinai Medical Center, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Mount Sinai Medical Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hari, Parameswaran N" sort="Hari, Parameswaran N" uniqKey="Hari P" first="Parameswaran N." last="Hari">Parameswaran N. Hari</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name>
<affiliation wicri:level="3"><nlm:aff id="A4">Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, UNITED KINGDOM</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K." last="Ballen">Karen K. Ballen</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Massachusetts General Hospital, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name>
<affiliation wicri:level="2"><nlm:aff id="A6">West Virginia University Hospitals, Inc., Morgantown, WV</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie-Occidentale</region>
</placeName>
<wicri:cityArea>West Virginia University Hospitals, Inc., Morgantown</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Olavarria, Eduardo" sort="Olavarria, Eduardo" uniqKey="Olavarria E" first="Eduardo" last="Olavarria">Eduardo Olavarria</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Hematology Department and BMT Unit, Complejo Hospitalario de Navarra, Pamplona, SPAIN</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Espagne</country>
<wicri:regionArea>Hematology Department and BMT Unit, Complejo Hospitalario de Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gerds, Aaron T" sort="Gerds, Aaron T" uniqKey="Gerds A" first="Aaron T." last="Gerds">Aaron T. Gerds</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Blood and Marrow Transplant Program, Medical University of South Carolina, Charleston, SC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Sud</region>
</placeName>
<wicri:cityArea>Blood and Marrow Transplant Program, Medical University of South Carolina, Charleston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H." last="Antin">Joseph H. Antin</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Dana Farber Cancer Institute, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Cell and Gene Therapy, Baylor College of Medicine, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Van Besien, Koen M" sort="Van Besien, Koen M" uniqKey="Van Besien K" first="Koen M." last="Van Besien">Koen M. Van Besien</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Stem Cell Transplant, Weill Cornell Medical College, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Stem Cell Transplant, Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Academische Ziekenhuis Maastricht, Maastricht, NETHERLANDS</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Academische Ziekenhuis Maastricht, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Clinical Haematology and BMT Service, Royal Melbourne Hospital, Victoria, AUSTRALIA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea>Clinical Haematology and BMT Service, Royal Melbourne Hospital, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
<affiliation wicri:level="3"><nlm:aff id="A17">Department of Hematology, University Hospital, Grenoble, FRANCE</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Lima, Marcos J" sort="De Lima, Marcos J" uniqKey="De Lima M" first="Marcos J." last="De Lima">Marcos J. De Lima</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name>
<affiliation wicri:level="2"><nlm:aff id="A19">Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name>
<affiliation wicri:level="1"><nlm:aff id="A20">King Faisal Specialist Hospital and Research Center, Riyadh, SAUDI ARABIA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Arabie saoudite</country>
<wicri:regionArea>King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea>
<wicri:noRegion>Riyadh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Popat, Uday" sort="Popat, Uday" uniqKey="Popat U" first="Uday" last="Popat">Uday Popat</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bejanyan, Nelli" sort="Bejanyan, Nelli" uniqKey="Bejanyan N" first="Nelli" last="Bejanyan">Nelli Bejanyan</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Mayo Clinic Rochester, Rochester, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Mayo Clinic Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Norkin, Maxim" sort="Norkin, Maxim" uniqKey="Norkin M" first="Maxim" last="Norkin">Maxim Norkin</name>
<affiliation wicri:level="2"><nlm:aff id="A19">Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Department of Hematology/Oncology, Shands HealthCare and University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide, AUSTRALIA</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea>Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital/SA Pathology, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name>
<affiliation wicri:level="2"><nlm:aff id="A25">All Children's Hospital, St. Petersburg, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>All Children's Hospital, St. Petersburg</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Woolfrey, Ann E" sort="Woolfrey, Ann E" uniqKey="Woolfrey A" first="Ann E." last="Woolfrey">Ann E. Woolfrey</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Baylor University Medical Center, Dallas, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Baylor University Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jagasia, Madan H" sort="Jagasia, Madan H" uniqKey="Jagasia M" first="Madan H." last="Jagasia">Madan H. Jagasia</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lill, Michael" sort="Lill, Michael" uniqKey="Lill M" first="Michael" last="Lill">Michael Lill</name>
<affiliation wicri:level="2"><nlm:aff id="A27">Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name>
<affiliation wicri:level="2"><nlm:aff id="A28">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Oregon</region>
</placeName>
<wicri:cityArea>Center for Hematologic Malignancies, Oregon Health and Science University, Portland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title>
<idno type="ISSN">1083-8791</idno>
<idno type="eISSN">1523-6536</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>HLA Antigens (immunology)</term>
<term>Hematopoietic Stem Cell Transplantation</term>
<term>Histocompatibility Testing</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Myeloablative Agonists (therapeutic use)</term>
<term>Primary Myelofibrosis (immunology)</term>
<term>Primary Myelofibrosis (mortality)</term>
<term>Primary Myelofibrosis (pathology)</term>
<term>Primary Myelofibrosis (therapy)</term>
<term>Prognosis</term>
<term>Recurrence</term>
<term>Risk</term>
<term>Siblings</term>
<term>Survival Analysis</term>
<term>Transplantation Conditioning (methods)</term>
<term>Transplantation, Homologous</term>
<term>Unrelated Donors (classification)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Agonistes myélo-ablatifs (usage thérapeutique)</term>
<term>Analyse de survie</term>
<term>Analyse multivariée</term>
<term>Antigènes HLA (immunologie)</term>
<term>Conditionnement pour greffe ()</term>
<term>Donneurs non apparentés ()</term>
<term>Femelle</term>
<term>Fratrie</term>
<term>Humains</term>
<term>Myélofibrose primitive ()</term>
<term>Myélofibrose primitive (anatomopathologie)</term>
<term>Myélofibrose primitive (immunologie)</term>
<term>Myélofibrose primitive (mortalité)</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Risque</term>
<term>Récidive</term>
<term>Sujet âgé</term>
<term>Test d'histocompatibilité</term>
<term>Transplantation de cellules souches hématopoïétiques</term>
<term>Transplantation homologue</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>HLA Antigens</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Myeloablative Agonists</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Myélofibrose primitive</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Unrelated Donors</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes HLA</term>
<term>Myélofibrose primitive</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Primary Myelofibrosis</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Transplantation Conditioning</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Primary Myelofibrosis</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Myélofibrose primitive</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Primary Myelofibrosis</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Primary Myelofibrosis</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agonistes myélo-ablatifs</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Hematopoietic Stem Cell Transplantation</term>
<term>Histocompatibility Testing</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Prognosis</term>
<term>Recurrence</term>
<term>Risk</term>
<term>Siblings</term>
<term>Survival Analysis</term>
<term>Transplantation, Homologous</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Analyse multivariée</term>
<term>Conditionnement pour greffe</term>
<term>Donneurs non apparentés</term>
<term>Femelle</term>
<term>Fratrie</term>
<term>Humains</term>
<term>Myélofibrose primitive</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Risque</term>
<term>Récidive</term>
<term>Sujet âgé</term>
<term>Test d'histocompatibilité</term>
<term>Transplantation de cellules souches hématopoïétiques</term>
<term>Transplantation homologue</term>
<term>Études de cohortes</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">We evaluated the outcomes and associated prognostic factors in 233 patients undergoing allogeneic hematopoietic cell transplantation (HCT) for primary myelofibrosis (MF) using reduced intensity conditioning (RIC). Median age at HCT was 55 years. Donors were: matched sibling donor (MSD), 34%; HLA-well-matched unrelated donors (URD), 45%; and partially/mismatched URD, 21%. Risk stratification according to Dynamic International Prognostic Scoring System (DIPSS): low, 12%; intermediate-1, 49%; intermediate-2, 37%; and high, 1%. The probability of survival at 5-years was 47% (95% CI 40–53). In a multivariate analysis, donor type was the only independent factor associated with survival. Adjusted probabilities of survival at 5-years for MSD, well matched URD and partially matched/mismatched URD were 56% (95% CI 44–67), 48% (95% CI 37–58), and 34% (95% CI 21–47), respectively (p=0.002). Relative risks (RR) for NRM for well-matched URD and partially matched/mismatched URD were 3.92 (p=0.006) and 9.37 (p<0.0001), respectively. A trend towards increased NRM (RR 1.7, p=0.07) and inferior survival (RR 1.37, p=0.10) was observed in DIPSS-intermediate-2/high-risk patients compared to DIPSS-low/intermediate-1 risk patients.</p>
<p id="P2">RIC HCT is a potentially curative option for patients with MF, and donor type is the most important factor influencing survival in these patients.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Arabie saoudite</li>
<li>Australie</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Californie</li>
<li>Caroline du Sud</li>
<li>Floride</li>
<li>Grand Londres</li>
<li>Géorgie (États-Unis)</li>
<li>Massachusetts</li>
<li>Minnesota</li>
<li>Ohio</li>
<li>Ontario</li>
<li>Oregon</li>
<li>Rhône-Alpes</li>
<li>Tennessee</li>
<li>Texas</li>
<li>Virginie-Occidentale</li>
<li>Wisconsin</li>
<li>État de New York</li>
</region>
<settlement><li>Grenoble</li>
<li>Londres</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Ontario"><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name>
</region>
</country>
<country name="États-Unis"><region name="État de New York"><name sortKey="Malone, Adriana K" sort="Malone, Adriana K" uniqKey="Malone A" first="Adriana K." last="Malone">Adriana K. Malone</name>
</region>
<name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
<name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H." last="Antin">Joseph H. Antin</name>
<name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K." last="Ballen">Karen K. Ballen</name>
<name sortKey="Bejanyan, Nelli" sort="Bejanyan, Nelli" uniqKey="Bejanyan N" first="Nelli" last="Bejanyan">Nelli Bejanyan</name>
<name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name>
<name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name>
<name sortKey="De Lima, Marcos J" sort="De Lima, Marcos J" uniqKey="De Lima M" first="Marcos J." last="De Lima">Marcos J. De Lima</name>
<name sortKey="Gerds, Aaron T" sort="Gerds, Aaron T" uniqKey="Gerds A" first="Aaron T." last="Gerds">Aaron T. Gerds</name>
<name sortKey="Hale, Gregory A" sort="Hale, Gregory A" uniqKey="Hale G" first="Gregory A." last="Hale">Gregory A. Hale</name>
<name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name>
<name sortKey="Hari, Parameswaran N" sort="Hari, Parameswaran N" uniqKey="Hari P" first="Parameswaran N." last="Hari">Parameswaran N. Hari</name>
<name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name>
<name sortKey="Jagasia, Madan H" sort="Jagasia, Madan H" uniqKey="Jagasia M" first="Madan H." last="Jagasia">Madan H. Jagasia</name>
<name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name>
<name sortKey="Kamble, Rammurti T" sort="Kamble, Rammurti T" uniqKey="Kamble R" first="Rammurti T." last="Kamble">Rammurti T. Kamble</name>
<name sortKey="Lill, Michael" sort="Lill, Michael" uniqKey="Lill M" first="Michael" last="Lill">Michael Lill</name>
<name sortKey="Litzow, Mark R" sort="Litzow, Mark R" uniqKey="Litzow M" first="Mark R." last="Litzow">Mark R. Litzow</name>
<name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name>
<name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name>
<name sortKey="Norkin, Maxim" sort="Norkin, Maxim" uniqKey="Norkin M" first="Maxim" last="Norkin">Maxim Norkin</name>
<name sortKey="Popat, Uday" sort="Popat, Uday" uniqKey="Popat U" first="Uday" last="Popat">Uday Popat</name>
<name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
<name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name>
<name sortKey="Van Besien, Koen M" sort="Van Besien, Koen M" uniqKey="Van Besien K" first="Koen M." last="Van Besien">Koen M. Van Besien</name>
<name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name>
<name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name>
<name sortKey="Woolfrey, Ann E" sort="Woolfrey, Ann E" uniqKey="Woolfrey A" first="Ann E." last="Woolfrey">Ann E. Woolfrey</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name>
</region>
</country>
<country name="Espagne"><noRegion><name sortKey="Olavarria, Eduardo" sort="Olavarria, Eduardo" uniqKey="Olavarria E" first="Eduardo" last="Olavarria">Eduardo Olavarria</name>
</noRegion>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name>
</noRegion>
<name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
</region>
</country>
<country name="Arabie saoudite"><noRegion><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004523 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004523 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3886623
   |texte=   REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24161923" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH

REDUCED INTENSITY HEMATOPOIETIC CELL TRANSPLANTATION FOR PATIENTS WITH PRIMARY MYELOFIBROSIS: A COHORT ANALYSIS FROM THE CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.